Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5260273 | Tetrahedron Letters | 2015 | 5 Pages |
Abstract
Modified Staudinger reaction is a well-established reaction for the amide synthesis from organic azides and carboxylic acids in the presence of phosphorous reagents. In contrary to this, it is notable that bis azide in the presence of triethylphosphite or trimethylphosphite does not afford the expected bis amides but affords the ethyl or methyl esters of the carboxylic acids respectively. This serendipitous observation when further investigated results in the discovery of bis azide-triphenylphosphine as an efficient reagent for esterification at room temperature.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Murugan Dinesh, Sivasubramaniyan Archana, Raja Ranganathan, Murugan Sathishkumar, Alagusundaram Ponnuswamy,