Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5261391 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A Brønsted acid promoted Csp3-H functionalization of 2-alkyl azaarenes with α-trifluoromethylated imino ester is described. A catalytic amount of triflic acid provided straightforward access to the corresponding trifluoromethylated amino esters via concomitant in situ one step N-alkyl deprotection. On further hydrolysis of ester, synthesis of quinoline derived unnatural trifluoromethylated amino acids has been achieved in a short and efficient manner.
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Authors
Mark Blocker, Supriya Immaneni, Abid Shaikh,