Article ID Journal Published Year Pages File Type
5261391 Tetrahedron Letters 2014 4 Pages PDF
Abstract
A Brønsted acid promoted Csp3-H functionalization of 2-alkyl azaarenes with α-trifluoromethylated imino ester is described. A catalytic amount of triflic acid provided straightforward access to the corresponding trifluoromethylated amino esters via concomitant in situ one step N-alkyl deprotection. On further hydrolysis of ester, synthesis of quinoline derived unnatural trifluoromethylated amino acids has been achieved in a short and efficient manner.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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