Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5261480 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
A series of new 11-aza-artemisinin derivatives were prepared from 11-aza-artemisinin using the Ugi reaction. An antimalarial activity evaluation against the FcB1 strain indicated that compounds 7, 10, and 16 had very strong inhibitory activity. Comparison of the activity among the synthetic derivatives of this series revealed that the length of the side chain R group on the amide nitrogen could be critical for their antimalarial properties.
Related Topics
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Authors
Thanh Nguyen Le, Wim M. De Borggraeve, Philippe Grellier, Van Cuong Pham, Wim Dehaen, Van Hung Nguyen,