Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5261498 | Tetrahedron Letters | 2014 | 6 Pages |
Abstract
An eight-step synthesis of cyclic dimeric methyl morpholinoside (c-di-MM), a common synthetic precursor to a number of cyclic dinucleotide analogs is reported. The synthesis of c-di-MM proceeds through a morpholine monomer prepared from readily available inexpensive starting materials and culminates with a key macrolactamization reaction to provide the macrocycle in 15% overall yield.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Charles R. Kinzie, Andrew D. Steele, Stacy M. Pasciolla, William M. Wuest,