| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5261595 | Tetrahedron Letters | 2014 | 6 Pages |
Abstract
A concise four-step efficient synthesis of honokiol 1 in 68% overall yield is described here. The present method involves tetrakis(triphenylphosphine)palladium [Pd(Ph3)4] catalyzed Kumada coupling in two key steps. First coupling generates biaryl backbone intermediate 5 and second generates 2,4â²-O-dimethylhonokiol 3. Final demethylation under AlCl3/DMS condition affords honokiol in quantitative yield.
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Authors
Jada Srinivas, Parvinder Pal Singh, Yogesh Kumar Varma, Irfan Hyder, Halmuthur M. Sampath Kumar,