Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5261609 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
Epicoccamides A and D were synthesized through a route that utilizes fragment coupling via olefin cross-metathesis as a key step. The right-hand segment of the epicoccamides was synthesized by a tandem O-acylation-migration reaction, and the left-hand segments were stereoselectively synthesized through a modified version of Crich's β-selective mannosylation. The previously assigned absolute configuration of the epicoccamide D was confirmed, and that of epicoccamide A was assigned as (5S,2â²S) based on the NMR and CD spectra. This Letter provides the first example of the total synthesis of epicoccamide A.
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Physical Sciences and Engineering
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Authors
Arata Yajima, Akihiro Kawajiri, Ayaka Mori, Ryo Katsuta, Tomoo Nukada,