Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5261614 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
Molecules with the quinone structure containing nitrogen constitute one of the most interesting classes of compounds in organic chemistry because of their biological properties and their potential as intermediates in the synthesis of heterocycles. This work describes a clean, efficient and facile one-pot protocol for the synthesis of a series of new aminonaphthoquinones derived from 2-hydroxy-1,4-naphthoquinone (lawsone) by three-component Mannich reaction using catalytic amount of p-TsOH at room temperature. At the present work, we improved the yield and significantly reduced the reaction time for several Mannich reactions with different amine and aromatic aldehydes using a non-expensive, mild catalyst and suitable solvent.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rodolfo G. Fiorot, João F. Allochio Filho, Thieres M.C. Pereira, Valdemar Jr., Reginaldo B. dos Santos, Wanderson Romão, Sandro J. Greco,