| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5261784 | Tetrahedron Letters | 2014 | 12 Pages |
Abstract
Antimalarial screening of diverse fungal samples resulted in the isolation and identification of a new sesquiterpene, trichothecinol D (1), which exhibited potent in vitro activity against Plasmodium falciparum with a 200-fold selectivity for parasite versus mammalian cytotoxicity. Trichothecinol D was obtained by bioassay-guided fractionation of two hyphomycete species. Its chemical characterization was performed by detailed NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of trichothecinol D was determined by X-ray crystallography.
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Authors
Carrie Waterman, Laurent Calcul, Tina Mutka, Dennis E. Kyle, Cedric J. Pearce, Bill J. Baker,