| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5262063 | Tetrahedron Letters | 2015 | 6 Pages |
Abstract
A convenient one-pot synthesis of 2-benzoxepines generated from (E)-2-nitro-3-arylprop-2-en-1-ols with paraformaldehyde via oxa-Pictet-Spengler cyclization is described. Furthermore, the 1,3-dipolar cycloaddition of 2-benzoxepines with azomethine ylides using isatin/paraformaldehyde led to the formation of tricyclic benzoxepinopyrrolidine and pentacyclic benzoxepinospiropyrrolidine oxindole architectures for the first time.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis of benzoxepinopyrrolidines/spiropyrrolidines via oxa-Pictet-Spengler and [3+2] cycloaddition reactions](/preview/png/5262063.png "First Page Preview: Synthesis of benzoxepinopyrrolidines/spiropyrrolidines via oxa-Pictet-Spengler and [3+2] cycloaddition reactions")
Authors
Manickam Bakthadoss, Nagappan Sivakumar, Anthonisamy Devaraj,