Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5262094 | Tetrahedron Letters | 2014 | 6 Pages |
Abstract
A tandem approach for the regio- and stereoselective synthesis of oxazolo-fused pyrroloquinolines 3a-l via the reaction of o-alkynylaldehydes 1a-i with chiral amino alcohols 2a-c under mild reaction conditions is described. The possible participation of pyridine ring in the regioselective formation of 5-exo-dig cyclized products was supported by the control experiments. The structures and stereochemistry of the products were confirmed by NOESY and X-ray crystallographic studies.
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Authors
Rajeev Ranjan Jha, Trapti Aggarwal, Akhilesh Kumar Verma,