Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5262266 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
An efficient approach for the synthesis of chiral P,O-ligands containing sulfonamide and phosphine moieties is designed. The introduction of the chirality is achieved through different stereogenic groups attached to the sulfonamide nitrogen. The highly effective sulfonamide directed ortho-lithiation and the subsequent reaction with ClPPh2 is the key step in the synthesis of the ligands. The prepared P,O-compounds are applied in Pd-catalyzed asymmetric allylic alkylation (AAA) under optimized conditions, to obtain high degrees of enantioselectivity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhanina Petkova, Malinka Stoyanova, Vladimir Dimitrov,