Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5262272 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
Thirteen nucleoside 5â²-triphosphates (NTPs) and their β,γ-bridging oxygen-modified analogs (β,γ-CX2-NTPs, X = H, F, Cl, and Br) have been efficiently synthesized from nucleoside 5â²-phosphoropiperidates with 4,5-dicyanoimidazole as the activator. A high-yielding and chromatography-free protocol for the preparation of both natural and base-modified nucleoside 5â²-phosphoropiperidates from the corresponding nucleoside 5â²-phosphates was also developed.
Related Topics
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Authors
Qi Sun, Shanshan Gong, Jian Sun, Chengjun Wang, Si Liu, Guodong Liu, Cha Ma,