Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5262699 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
The conversion of the C40 secondary hydroxyl group of rapamycin into the azido group was followed by copper catalyzed cycloaddition of the resulting azido-rapamcin with various unprotected propargyl O- and S-glycosides and a C-ethynyl derivative. This approach furnished a collection of triazole-bridged rapamycin glycoconjugates (14 examples) in 44-83% isolated yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lisa Moni, Alberto Marra, Jerauld S. Skotnicki, Frank E. Koehn, Magid Abou-Gharbia, Alessandro Dondoni,