| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5262923 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
An unprecedented multi-component reaction for the synthesis of thiosugar-annulated 1,3-thiazines is reported. The envisaged synthetic strategy involves the reaction of d-glucose/d-xylose and 2-methyl-2-phenyl-1,3-oxathiolan-5-one with AcONH4/RNH2 in task specific ionic liquid (TSIL), [bmim]SCN which afforded thiosugar annulated 1,3-thiazines in excellent yields (83-93%). The reaction is effected via ionic liquid promoted Michael addition followed by mercaptoacetylative ring transformation in a one-pot procedure and the ionic liquid, [bmim]OH could be easily recycled for further use without any loss of efficiency and be used for the synthesis of [bmim]SCN, thus allowing recycling of the TSIL for further use.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vijai K. Rai, Prashant Kumar Rai, Yogita Thakur,