| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5263038 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
This Letter describes an attractive and efficient method for Mg(OR)2-mediated lactide alcoholysis. The catalysts were generated in situ from di-n-butylmagnesium and ROH to prevent aggregation of Mg(OR)2. The reaction of ROH [R = Me, Et, RCO2(Me)CH] with lactide initially yielded the ring-opened product HO[CH(CH3)CO]nOR (n = 2 or 3). The complete consumption of lactide caused the reaction to proceed further, giving environmentally friendly lactic acid esters in excellent yields under ambient conditions.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dominik Bykowski, Agnieszka Grala, Piotr Sobota,