Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263128 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A novel copper-catalyzed, base-free direct thiolation of xanthines and related heterocycles is described, featuring the use of inexpensive Cu(OAc)2·H2O as the catalyst, O2 as a clean and cheap oxidant, and easy-to-handle disulfides as the thiolation reagents. It works well for both aryl and alkyl disulfides. Moreover, the resultant products can be converted into 8-(hetero)aryl- or alkenyl-substituted xanthines in good yields via the Liebeskind-Srogl coupling reaction.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zuying He, Fang Luo, Yinglong Li, Gangguo Zhu,