Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263501 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
A copper-catalyzed asymmetric propargylic amination with a chiral ketimine P,N,N-ligand that proceeds via decarboxylation of propargyl carbamates has been developed. The reaction can be performed under the mild condition for a broad range of substrates, providing the corresponding propargylic amines in high yields and with up to 97% ee. This reaction represents a new and facile access to optically active propargylic amines.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuan Zou, Fu-Lin Zhu, Zheng-Chao Duan, Ya-Hui Wang, De-Yang Zhang, Zhong Cao, Zhuo Zheng, Xiang-Ping Hu,