Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263573 | Tetrahedron Letters | 2014 | 6 Pages |
Abstract
Direct reductive amination (DRA) using triethylsilane (TESH) and catalytic bismuth(III) chloride (BiCl3) is described for the first time. The use of TESH and BiCl3 provides easy handling, low cost, non-toxicity, and a mild Lewis acid activity, thereby meeting the demand for green and sustainable chemistry. The developed DRA is highly chemoselective and applicable to less-basic amines. The experimental results of this study revealed that the developed DRA could be catalyzed by BiCl3, which was gradually reduced to Bi(0) or bismuth with a low valency by TESH, but TESCl, Bi(0), and Bi(0) with TESCl catalyzed the DRA to some extent.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Takehiko Matsumura, Masahisa Nakada,