Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263878 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
Novel, one-pot, three-component reactions of the zwitterions generated in situ from pyridine and acetylenic esters with alkoxymethylenemalononitriles via 1,4-dipolar cycloadditions are described. The reactions afforded dialkyl 1,1-dicyano-2-alkoxy-1,9a-dihydro-2H-quinolizine-3,4-dicarboxylate derivatives in good to high yields without using any catalyst or activation. Structural, electronic, energetic, and mechanistic details of the reaction are also revealed by density functional theory (DFT) calculations, which strongly support the exclusive formation of the observed products.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Abbas Ali Esmaeili, Farzaneh Zarifi, Abbas Moradi, Mohammad Izadyar, Ali Reza Fakhari,