Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263905 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
Direct, chemo-specific arylation at C-2 or N-4 of 1,4-benzothiazin-3-one with aryl halides, based on Pd or Cu catalyst system, respectively, provided easy entry to arylated derivatives, a class of molecules not easily accessible via existing methods. Under Pd-catalysis conditions with LiHMDS as the base, N-arylation of 1,4-benzothiazin-3-one was inhibited leading to Cα-arylation of a secondary amide without the need for protection and de-protection of more acidic amido NH.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wei-Sheng Huang, Rongsong Xu, Rory Dodd, William C. Shakespeare,