Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5263912 | Tetrahedron Letters | 2014 | 8 Pages |
Abstract
The synthesis of 4-hydroxymethyl-2,4-methanoproline, a novel conformationally restricted amino acid, was performed in four steps. This close analogue of naturally occurring amino acids (i.e., proline, hydroxyproline, serine and threonine) was prepared in good overall yield through two intramolecular recyclization reactions of cyclobutane derivatives.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Roman I. Vasiuta, Marian V. Gorichko,