| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5263998 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A mild procedure for the conjugate addition of the trifluoromethyl anion to activated Michael acceptors such as arylidenemalononitriles (15 examples) and arylidene Meldrum's acids (9 examples) using phenyl trifluoromethyl sulfone through a reductive magnesium metal mediated procedure is described. The new methodology is used to prepare befloxatone, a reversible and selective monoamine oxidase A inhibitor.
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Authors
Kaumba Sakavuyi, Kimberly S. Petersen,