Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264057 | Tetrahedron Letters | 2014 | 6 Pages |
Abstract
An unusual rearrangement of a 1-oxa-6-azaspiro[2.5]octane derivative giving access to novel 5-substituted 2-azabicyclo[3.1.0]hexanes is described. The synthetic application of the reaction is demonstrated by the synthesis of N-Boc-2,3-methano-β-proline. The amino acid was prepared through a three-step synthesis from easily available reagents in an overall yield of 15%.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mykhailo I. Adamovskyi, Oleksiy S. Artamonov, Andriy V. Tymtsunik, Oleksandr O. Grygorenko,