Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264089 | Tetrahedron Letters | 2013 | 6 Pages |
Abstract
An atom transfer radical dearomatizing spirocyclization from N-benzyltrichloroacetamides using CuCl regioselectively leads to 2-azaspiro[4.5]decadienes, in which the labile allylic chlorine atom is easily replaced by a hydroxyl group in aqueous medium or by quenching with methanol or allylamine. After oxidation of the target compound, the N-tert-butyl group can be removed from the resulting spirocyclohexanedienone.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Faïza Diaba, Juan A. Montiel, AgustÃn MartÃnez-Laporta, Josep Bonjoch,