Article ID Journal Published Year Pages File Type
5264132 Tetrahedron Letters 2013 5 Pages PDF
Abstract
In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.
Keywords
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Efficient and scalable synthesis of ketones via nucleophilic Grignard addition to nitriles using continuous flow chemistry
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