Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264132 | Tetrahedron Letters | 2013 | 5 Pages |
Abstract
In the present Letter we report the development of efficient continuous flow chemistry conditions for the scalable preparation of ketones. This transformation is achieved via nucleophilic addition of Grignard reagents to the corresponding nitriles and imine hydrolysis by means of in-series plug flow reactors.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carlos Mateos, Juan A. Rincón, José Villanueva,