Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264290 | Tetrahedron Letters | 2013 | 6 Pages |
Abstract
The direct alkylation of indoles using KOH and alcohols, as initial source of the electrophile, under solvent-free conditions is a safe and environmentally benign strategy for selective modification of these structures at the C3-position, without using hazardous and difficult to handle bromide or iodide derivatives or toxic and expensive transition metal catalysts. The protocol shows a broad scope, including halogenated indoles and secondary alcohols.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rafael Cano, Miguel Yus, Diego J. Ramón,