| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5264371 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
A convenient method for oxidative decarboxylation of α-amino acids is presented. The aldehyde products may be isolated or converted to tetrahydroisoquinolines by addition of dopamine via Pictet-Spengler reaction. Racemic products are generated by phosphate buffer >300 mM to maximize regioselectivity. (S)-Enantiomer products are generated by norcoclaurine synthase reaction in maleic acid buffer to minimize chemical background reaction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Justin J. Maresh, Sean O. Crowe, Arthur A. Ralko, Mark D. Aparece, Casey M. Murphy, Mark Krzeszowiec, Michael W. Mullowney,