Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264375 | Tetrahedron Letters | 2014 | 7 Pages |
Abstract
Aromatic, allylic, and aliphatic compounds containing a chlorohydrin group were selected as substrates for the enzymatic kinetic resolution mediated by Amano AK lipase from Pseudomonas fluorescens immobilized in silk friboin-alginate spheres. Thus, the enantioselectivity of the process was sufficient for the production of the desired alcohols and acetates in good yields and high enantiomeric purities. This Letter provides a simple, cheap, and practical protocol for enantioselective synthesis of chlorohydrins and reinforces the versatility of silk fibroin as supports for heterogeneous catalysts.
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Authors
Irlon M. Ferreira, Rodolfo H.V. Nishimura, Ana B. dos A. Souza, Giuliano C. Clososki, Sergio A. Yoshioka, André L.M. Porto,