Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264407 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
Azetidines containing a basic ring nitrogen atom have been shown to undergo facile ring cleavage to afford 3-halo-1-amino propane derivatives upon exposure to alkyl bromides and acyl chlorides under certain conditions. Alkylation of NH azetidines to afford N-alkyl azetidines can be carried out in synthetically useful yields if reaction times are kept short. As the free base, azetidines may undergo spontaneous oligomerization with concomitant ring cleavage.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jun Xiao, Stephen W. Wright,