Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264451 | Tetrahedron Letters | 2005 | 5 Pages |
Abstract
A practical one-pot procedure for the preparation of N-H isoquinolones has been developed. This 2-step process via C-H activation of N-alkoxyl benzamides and NaH-mediated dealkoxylation reaction has been demonstrated to be a high yielding alternative methodology for the efficient synthesis of a wide range of representative N-H isoquiolones. In addition, the experimental precedent supported mechanism of the dealkoxylation reaction was also proposed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shaonan Lu, Yingfu Lin, Hongban Zhong, Kang Zhao, Jianhui Huang,