Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264514 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
Two novel stereoisomeric analogues of 1,25-dihydroxyvitamin D3 bearing a spiro-oxetane at the C3 position of the A-ring have been designed and synthesized in a convergent manner. The absolute configuration at the C1 position of the synthesized compounds was determined by the circular dichroism exciton chirality method using the corresponding C1-allylic benzoates. The replacement of the C3-hydroxy group with a spiro-oxetane provided an advantageous conformational preference for the parent seco-steroids, which would facilitate the formation of a stable receptor complex.
Related Topics
Physical Sciences and Engineering
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Authors
Toshie Fujishima, Tsutomu Suenaga, Takato Nozaki,