Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264535 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A series of novel thiadiaza and triaza crown ether attached galactose- and glucose-based glycolipids is synthesized, applying a new strategy. The key step is the formation of α-chloroacetamido precursors (14 and 21) from selectively protected bis(cyanomethyl)-glycolipids (13 and 19) in two steps. The cyclization reaction furnishes good yields in relatively short times in aqueous ethanol or acetonitrile. To generalize this method, macrocycles 3 and 25 are reported as well. Attempts to use the traditional synthetic approaches for cyclization failed to provide reasonable yields.
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Authors
Karem J. Sabah, Rauzah Hashim,