Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264538 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Haijun Chen, Chunyong Ding, Christopher Wild, Huiling Liu, Tianzhi Wang, Mark A. White, Xiaodong Cheng, Jia Zhou,