Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264691 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
We herein report the synthesis of a series of 12 optically pure 3,4-dihydro-1H-pyrido-[1â²,2â²:1,2]-imidazo[4,5-d][1,3]diazepine-2,5-diones, which form a new family of azaheterocycle-fused [1,3]diazepines. The key step of the synthesis consists in a selective C-acylation of 2-amino-imidazo[1,2-a]pyridine by various natural amino-acids, followed by an intracarbonylation reaction.
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Authors
Dominique P. Arama, Vincent Lisowski, Eliana Scarlata, Pierre Fulcrand, Ludovic T. Maillard, Jean Martinez, Nicolas Masurier,