Article ID Journal Published Year Pages File Type
5264705 Tetrahedron Letters 2013 4 Pages PDF
Abstract
Various difluoropyridoindoles were synthesized via a palladium-catalyzed intramolecular Heck reaction as a key step. Thus, ortho-bromoanilines and difluoropiperidinone were treated with (PPh3)2PdCl2 and base in pyridine to give the regioselective cyclized heterocycles in modest to satisfactory yields.
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Physical Sciences and Engineering Chemistry Organic Chemistry
Preview
Novel synthesis of 4,4-difluoropyrido[4,3-b]indoles via intramolecular Heck reaction
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