Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264719 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A series of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles were synthesized via [3+2] cycloaddition of α-acyl ketene dithioacetals (or related substrates) with commercially available propargylamines as 1,3-dipoles in water. Most of the reactions can be performed in the absence of an external base. The reaction of secondary amine (N-methylprop-2-yn-1-amine) with α-acyl ketene dithioacetals showed different reaction behaviours depending on the addition or absence of an external base.
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Authors
Chuan-Qing Ren, Chong-Hui Di, Yu-Long Zhao, Jing-Ping Zhang,