Article ID Journal Published Year Pages File Type
5264723 Tetrahedron Letters 2013 8 Pages PDF
Abstract
A facile protocol for direct access to chromeno-pyrimidine-N-oxides is reported by the reaction of 4-chloro-3-formylcoumarin and aromatic carboximide oximes via tandem double nucleophilic addition and dehydration reactions. The one-pot reaction serves as an alternative protocol for achieving regioselective pyrimidine mono-N-oxide products as pure precipitates in good to excellent yields. The structure of the product was confirmed by X-ray analysis.
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Physical Sciences and Engineering Chemistry Organic Chemistry
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