| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5264733 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
During synthetic studies toward strictamine, unexpected oxidation of tertiary amine to enamine was observed in ring-closing olefin metathesis (RCM) using Hoveyda-Grubbs 2nd catalyst. Control experiments under deoxygenated conditions indicated Ru-catalyst and electron deficient 1,4-benzoquinone additive promoted oxidation. The desired RCM reaction took place selectively under microwave irradiation by suppression of oxidation of amine.
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Authors
Yoshiyuki Komatsu, Kei Yoshida, Hirofumi Ueda, Hidetoshi Tokuyama,