| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5264911 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The synthesis of 3-pyrazinyl-pyrazolo[1,5-a]pyridines from an enol ether and 4-substitued 1- aminopyridinium iodides via a 3+2 cycloaddition is presented. A high throughput reaction screen was used to optimize the yield of the cycloaddition. This protocol is operationally simple, scalable, proceeds at room temperature and the reaction profiles are very clean.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether](/preview/png/5264911.png "First Page Preview: The Synthesis of 3-pyrazinyl-pyrazolo [1,5-a] pyridines from an enol ether")
Authors
Michelle Tran-Dubé, Neal Sach, Sacha Ninkovic, John F. Braganza, Qinhua Huang, Benjamin Johnson, Michael Raymond Collins,