Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5264946 | Tetrahedron Letters | 2014 | 5 Pages |
Abstract
A one-pot, highly efficient and diastereoselective construction of 1,2-dihyro-10â²bH-spiro[indole-3,1â²-pyrazole[3,2-a]isoquinoline]-2â²-carboxylates via silver triflate-catalyzed [3+2] cycloaddition of Nâ²-(2-alkynylbenzylidene)hydrazide with methyleneindolinones in good to excellent yield has been described. The transformation involves initially a condensation followed by 6-endo-intramolecular cyclization forming dipole which then undergoes [3+2]-cycloaddition with methyleneindolinones and finally, β-hydrogen elimination.
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Authors
Panneerselvam Yuvaraj, Boreddy S.R. Reddy,