| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5264966 | Tetrahedron Letters | 2014 | 4 Pages |
Abstract
An efficient one-pot route to synthesize tertiary alcohol compounds using Barbier-Grignard reaction of unactivated alkyl or aryl bromides with ester in THF at 65 °C catalyzed by CuO has been developed and systematically investigated. A wide range of substituted tertiary alcohol compounds were obtained in good to high yields. The reaction is highly chemoselective. The mechanism involving the leaving group of R2O-group is discussed.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fei Gao, Xiang-Jun Deng, Yu Tang, Jin-Peng Tang, Jun Yang, Yuan-Ming Zhang,