| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5265286 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
The Suzuki cross-coupling between 2-(4-bromophenyl)-5-chloropyrazine and a range of aryl boronic acids has been investigated. The regioselectivity of the reaction can be switched between the aryl bromide and pyrazinyl chloride positions by changing the ligand associated with the palladium catalyst. Xantphos has shown excellent selectivity for the pyrazinyl chloride, with most other ligands showing preferential selectivity for the aryl bromide.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christopher P. Ashcroft, Steven J. Fussell, Katie Wilford,