Four component reaction of aldehydes, isocyanides, Me3SiN3, and aliphatic alcohols catalyzed by indium triflate

In the presence of catalytic amount of indium(III) Lewis acids, the four component reaction of aldehydes, isocyanides, trimethylsilyl azide and aliphatic alcohols smoothly proceeded to give alkoxylated 1H-tetrazole products in good yields. In particular, In(OTf)3 and In(ONf)3 showed notably high level of catalytic activity in this reaction.