Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265416 | Tetrahedron Letters | 2013 | 12 Pages |
Abstract
An environmentally benign and operationally simple methodology was developed for the synthesis of 3-benzyl-3-(indol-3-yl)-2-phenyl-2,3-dihydroisoindolinones via multicomponent one-pot reaction involving 2-iodo-N-phenylbenzamides, terminal alkyne, and substituted indoles in aqueous micellar medium. It involves copper-mediated domino Sonogashira-5-exo-dig-cyclization followed by regioselective nucleophilic addition of indoles, all in one-pot, using CuI as catalyst and 2,2â²-(1E,1â²E)-(1R,2R)-cyclohexane-1,2-diylbis(azan-1-yl-1-ylidene)bis(methan-1-yl-1-ylidene)diphenol as ligand under aerobic condition.
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Authors
Swarbhanu Sarkar, Rammyani Pal, Asish Kumar Sen,