| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5265418 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A new 2â²-OH protecting group, {[2,2-dimethyl-2-(2-nitrophenyl)acetyl]oxy} methyl (DAM), has been successfully applied to RNA oligonucleotides synthesis with high coupling efficiency. The 2â²-O-DAM method is fully compatible with reagents and conditions employed in automated solid phase synthesis of RNA. Moreover, it can be easily removed via reduction in near-neutral solution.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![2â²-O-{[2,2-dimethyl-2-(2-nitrophenyl) acetyl] oxy} methyl protecting group for RNA synthesis](/preview/png/5265418.png "First Page Preview: 2â²-O-{[2,2-dimethyl-2-(2-nitrophenyl) acetyl] oxy} methyl protecting group for RNA synthesis")
Authors
Ke Chen, Wei Wang, Dezhong Qu, Haoting Zhao, Wei Xiong, Caijie Luo, Menghui Yin, Biliang Zhang,