Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265490 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
An efficient approach for the synthesis of coumarin-, quinolone- and pyridine-annulated oxazole derivatives has been achieved by direct base-mediated intramolecular carbon-oxygen bond formation in a transition metal catalyst-free protocol. Intramolecular cyclization of o-bromoamides in DMSO in the presence of Cs2CO3 at 130 °C affords heterocycle-annulated oxazole derivatives in high yields via a nucleophilic addition of amide to form the C-O bond.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
K.C. Majumdar, Sintu Ganai, Raj Kumar Nandi, Krishanu Ray,