Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265514 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
The ability of zinc chloride as a catalyst to promote the three-component Ugi reaction of 2-aminophenols, aliphatic or aromatic aldehydes, and cyclohexyl isocyanide in methanol at room temperature is described. The N-cyclohexyl-2-(2-hydroxyphenylamino) amide products are obtained in high yields. When N,N-dimethylformamide dimethyl acetal and triethyl orthoformate, as two new components of the three-component Ugi reaction are used instead of the aldehyde the reaction gives N-cyclohexyl-2-(dimethylamino)-2-(2-hydroxyphenylamino)acetamide and N-cyclohexyl-2-(2-hydroxyphenylamino)-2-ethoxyacetamide derivatives, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ahmad Shaabani, Sajjad Keshipour, Shabnam Shaabani, Mojtaba Mahyari,