| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5265714 | Tetrahedron Letters | 2013 | 4 Pages |
Abstract
A facile stereoselective synthesis of a series of nineteen novel bis-(trans-2,3-dihydrofuranyl) sulfides from the reaction of (Z,Z)-2,2â²-thiobis(1,3-diarylprop-2-en-1-ones) with substituted phenacyl bromides and pyridine in the presence of K2CO3 in acetonitrile via domino reactions is described. This transformation presumably occurs via pyridinium salt formation/ylide generation/Michael addition/intramolecular annulation domino sequence, involving the formation of two C-C and two C-O bonds and four stereocentres in a single step with complete stereoselectivity affording only one diastereomer.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Beer Mohamed Vinosha, Subbu Perumal, Subbiah Renuga, Abdulrahman I. Almansour,