Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265754 | Tetrahedron Letters | 2012 | 4 Pages |
Abstract
InBr3 promoted three-component reactions of an aryldiazoacetate, an alcohol, and an electron deficient carbonyl compound gave α,β-dihydroxyl acid derivatives in good yield with high diastereoselectivity. The reaction is proposed through a protic oxonium ylide trapping process. The reaction mechanism for the formation of the protic oxonium ylide via Lewis acid InBr3 catalyzed diazo decomposition is suggested through a vinyl cationic intermediate.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jingjing Ji, Xia Zhang, Liqing Jiang, Wenhao Hu,