Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5265756 | Tetrahedron Letters | 2012 | 5 Pages |
Abstract
A highly efficient, environmentally safe and economic method for selective α-monobromination of aralkyl, cyclic, acyclic, 1,3-diketones and β-keto esters and α,α-dibromination of 1,3-diketones and β-keto esters without catalyst is reported using ammonium bromide as a bromine source and oxone® as an oxidant. The reaction proceeds at ambient temperature and yields range from moderate to excellent. Bromination of unsymmetrical ketones takes place at the less substituted α-position predominantly. Aromatisation of tetralones is also carried out with this reagent system.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Arun Kumar Macharla, Rohitha Chozhiyath Nappunni, Mahender Reddy Marri, Swamy Peraka, Narender Nama,